The HPA is a National Professional Group within the Health Sector of Unite (Amicus). It is organised into twelve Regional Groups consistent with the English Regional Development Agency boundaries and the three devolved administrations as follows:
| 1 | Northern | Northumbria, Tyne and Wear, Co. Durham and Tees Valley |
| 2 | Yorkshire / Humber | North, West and South Yorkshire and Humberside |
| 3 | East Midlands | Derbys, Leices, Lincs, Northants and Nottingham |
| 4 | East of England | Beds, Cambs,Essex, Herts, Norfolk and Suffolk |
| 5 | London | |
| 6 | South East | Berks, Bucks, Hants, Kent, Oxforshire, Surrey, Sussex and Isle of Wight |
| 7 | South West | Cornwall, Devon, Dorset, Gloucs, Somerset, Wiltshire and Avon |
| 8 | West Midlands | Shrops, Staffs, Herefs, Warcs, Worcs, Birmingham, Coventry and Wolverhampton |
| 9 | North West | Cumbria, Cheshire, Lancs, Greater Manchester, and the Wirral |
| 10 | Scotland | |
| 11 | Northern Ireland | |
| 12 | Wales |